Search PLR Content Marketing Palau: September 2016

Friday, September 30, 2016

Barigraf

Barigraf may be available in the countries listed below.

Ingredient matches for Barigraf

Barium Sulfate

Barium Sulfate is reported as an ingredient of Barigraf in the following countries:

Argentina

Spain

International Drug Name Search

Vecuronium Bromide

Generic Name: vecuronium (VEK ue ROE nee um)

Brand Names: Vecuronium Bromide

What is Vecuronium Bromide (vecuronium)?

Vecuronium is used to relax the muscles. It works by blocking the signals between your nerves and your muscles.

Vecuronium is given before general anesthesia in preparing you for surgery. Vecuronium helps keep your body still during surgery. It also relaxes your throat so a breathing tube can be more easily inserted before the surgery.

Vecuronium may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Vecuronium Bromide (vecuronium)?

Before receiving vecuronium, tell your doctor if you are allergic to any drugs, or if you have kidney disease, heart disease or congestive heart failure, problems with circulation, or a nerve-muscle disorder such as ALS (Lou Gehrig's disease), MS (multiple sclerosis), or muscular dystrophy.

Tell your doctor if you are pregnant or breast-feeding.

It may take you longer to recover from the effects of vecuronium if you have cirrhosis or other liver disease.

Follow your doctor's instructions about any restrictions on food, beverages, or activity after you recover from anesthesia.

What should I discuss with my health care provider before receiving Vecuronium Bromide (vecuronium)?

You should not receive this medication if you are allergic to vecuronium.

Before receiving vecuronium, tell your doctor if you are allergic to any drugs, or if you have:

myasthenia gravis;

cirrhosis or other liver disease;

a history of kidney disease;

heart disease or congestive heart failure;

problems with circulation; or

a nerve-muscle disorder such as ALS (Lou Gehrig's disease), MS (multiple sclerosis), or muscular dystrophy.

If you have any of these conditions, you may not be able to receive vecuronium, or you may need dosage adjustments or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Before receiving vecuronium, tell your doctor if you are breast-feeding a baby.

How is vecuronium given?

Vecuronium is given as an injection through a needle placed into a vein or muscle. You will receive this injection in a hospital or surgical setting.

Your caregivers will monitor your heart function, blood pressure, and breathing while you are under the effects of vecuronium.

It may take you longer to recover from the effects of vecuronium if you have cirrhosis or other liver disease.

What happens if I miss a dose?

Since vecuronium is usually given just for anesthesia, you are not likely to be on a dosing schedule.

What happens if I overdose?

An overdose of vecuronium is unlikely to occur since the medication is given by a doctor. Your vital signs will be closely watched while you are under anesthesia to make sure the medication is not causing any harmful effects.

What should I avoid after receiving Vecuronium Bromide (vecuronium)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity after you recover from anesthesia.

Vecuronium Bromide (vecuronium) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers right away if you have any of these serious side effects:

trouble breathing;

ongoing muscle weakness; or

inability to move your muscles.

Less serious side effects may include:

feeling light-headed; or

itching.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Vecuronium Bromide (vecuronium)?

There may be other drugs that can interact with vecuronium. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors.

More Vecuronium Bromide resources

Vecuronium Bromide Side Effects (in more detail)
Vecuronium Bromide Use in Pregnancy & Breastfeeding
Vecuronium Bromide Drug Interactions
Vecuronium Bromide Support Group
0 Reviews for Vecuronium Bromide - Add your own review/rating

Vecuronium Bromide Professional Patient Advice (Wolters Kluwer)

Vecuronium Bromide Monograph (AHFS DI)

Vecuronium Prescribing Information (FDA)

Vecuronium MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Vecuronium Bromide with other medications

Anesthesia

Where can I get more information?

Your doctor or pharmacist can provide more information about vecuronium.

See also: Vecuronium Bromide side effects (in more detail)

telmisartan

tel-mi-SAR-tan

Oral route(Tablet)

Drugs that act directly on the renin-angiotensin system can cause injury or death to the developing fetus. Stop therapy as soon as possible when pregnancy is detected .

Commonly used brand name(s)

In the U.S.

Micardis

Available Dosage Forms:

Tablet

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Angiotensin II Receptor Antagonist

Uses For telmisartan

Telmisartan is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Telmisartan is also used to lower the risk of heart attack or stroke in patients 55 years of age and older who have been diagnosed with diabetes or heart or blood vessel problems.

Telmisartan is an angiotensin II receptor blocker. It works by blocking a substance in the body that causes blood vessels to tighten. As a result, telmisartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.

telmisartan is available only with your doctor's prescription.

Before Using telmisartan

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For telmisartan, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to telmisartan or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of telmisartan in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of telmisartan in the elderly.

Pregnancy

	Pregnancy Category	Explanation
1st Trimester	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
2nd Trimester	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.
3rd Trimester	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking telmisartan, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using telmisartan with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Benazepril

Enalapril

Enalaprilat

Lisinopril

Moexipril

Perindopril

Quinapril

Ramipril

Trandolapril

Using telmisartan with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Bromfenac

Celecoxib

Diclofenac

Diflunisal

Digoxin

Etodolac

Fenoprofen

Flurbiprofen

Ibuprofen

Indomethacin

Ketoprofen

Ketorolac

Lithium

Magnesium Salicylate

Meclofenamate

Mefenamic Acid

Meloxicam

Nabumetone

Naproxen

Nepafenac

Oxaprozin

Piroxicam

Salsalate

Sulindac

Tolmetin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of telmisartan

In addition to the use of the medicine your doctor has prescribed, treatment for your high blood pressure may include weight control and a change in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that telmisartan will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

telmisartan also works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at the same time each day.

telmisartan comes with a patient information insert. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

You may take telmisartan with or without food.

Dosing

The dose of telmisartan will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of telmisartan. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):
- For high blood pressure:
  - Adults—At first, 40 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 80 mg per day.
  - Children—Use and dose must be determined by your doctor.
- To lower the risk of heart or blood vessel problems:
  - Adults 55 years of age and older—80 milligrams (mg) once a day.
  - Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of telmisartan, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Protect the tablets from moisture and do not remove from the blister pack until you are ready to use them.

Precautions While Using telmisartan

It is very important that your doctor check your progress at regular visits to make sure that telmisartan is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using telmisartan while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using telmisartan, tell your doctor right away.

telmisartan may cause some people to become drowsy, dizzy, or less alert than they are normally. Make sure you know how you react to telmisartan before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Dizziness, lightheadedness, or fainting may also occur, especially when you get up from a lying or sitting position. Getting up slowly may help. These symptoms are more likely to occur when you begin taking telmisartan, or when the dose is increased.

Check with your doctor right away if you become sick while taking telmisartan, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt and may lead to low blood pressure.

Check with your doctor right away if you experience dizziness, fainting, confusion, muscle pain, weakness, and/or a fast heartbeat. Use extra care if you exercise or if the weather is hot. Heavy sweating can cause dehydration (loss of too much water) or electrolyte imbalances (loss of potassium, magnesium, or sodium in the body).

Hyperkalemia (high potassium in the blood) may occur while you are using telmisartan. Check with your doctor right away if you have the following symptoms: abdominal or stomach pain; confusion; difficulty with breathing; irregular heartbeat; nausea or vomiting; nervousness; numbness or tingling in the hands, feet, or lips; shortness of breath; or weakness or heaviness of the legs.

Make sure any doctor or dentist who treats you knows that you are using telmisartan. telmisartan may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may increase your blood pressure.

telmisartan Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Changes in vision

dizziness, lightheadedness, or fainting

fast heartbeat

large hives

painful urination or changes in urinary frequency

swelling in the hands, lower legs, and feet

Incidence not known

Blurred vision

chest pain or discomfort

confusion

dark-colored urine

decreased urine output

difficult breathing

dilated neck veins

extreme fatigue

fast or irregular heartbeat

flushing

hives or welts

hoarseness

irregular breathing

irritation

itching

joint pain, stiffness, or swelling

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

muscle cramps or stiffness

numbness or tingling in the hands, feet, or lips

pain or discomfort in the arms, jaw, back, or neck

pounding in the ears

rash

redness of the skin

shortness of breath

slow or fast heartbeat

sweating

swelling of the eyelids, face, or lips

tightness in the chest

troubled breathing or swallowing

trouble with speaking or walking

trouble with thinking

unusual tiredness or weakness

unusually warm skin

weakness or heaviness of the legs

weakness, numbness, or tingling in the arms or legs

weight gain

wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Abdominal or stomach pain

back pain

bloating or gas

changes in appetite

coughing

diarrhea

dry mouth

ear pain or hearing problems

fever

general tiredness or weakness

headache

heartburn

increased sweating

muscle pain or spasm

nausea

nervousness

runny or stuffy nose

sneezing

sore throat

Incidence not known

Acid or sour stomach

belching

decreased interest in sexual intercourse

difficulty with moving

inability to have or keep an erection

indigestion

joint pain

lack or loss of strength

leg cramps

loss in sexual ability, desire, drive, or performance

muscle aching

stomach discomfort, upset, or pain

swelling

weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: telmisartan side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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More telmisartan resources

Telmisartan Side Effects (in more detail)
Telmisartan Dosage
Telmisartan Use in Pregnancy & Breastfeeding
Telmisartan Drug Interactions
Telmisartan Support Group
18 Reviews for Telmisartan - Add your own review/rating

Telmisartan Professional Patient Advice (Wolters Kluwer)

Telmisartan Monograph (AHFS DI)

Telmisartan MedFacts Consumer Leaflet (Wolters Kluwer)

Micardis Prescribing Information (FDA)

Micardis Consumer Overview

Compare telmisartan with other medications

Cardiovascular Risk Reduction
High Blood Pressure
Prevention of Cardiovascular Disease

Co-Dafalgan

Co-Dafalgan may be available in the countries listed below.

Ingredient matches for Co-Dafalgan

Codeine

Codeine phosphate hemihydrate (a derivative of Codeine) is reported as an ingredient of Co-Dafalgan in the following countries:

Switzerland

Paracetamol

Paracetamol is reported as an ingredient of Co-Dafalgan in the following countries:

Switzerland

International Drug Name Search

Thursday, September 29, 2016

Tagamet 800mg Tablets

1. Name Of The Medicinal Product

Tagamet 800 mg Tablets

2. Qualitative And Quantitative Composition

Each tablet contains Cimetidine 800 mg.

For excipients, see 6.1.

3. Pharmaceutical Form

Film-coated tablet.

Pale green, oval, film-coated tablet engraved with Tagamet on one face and 800 on the reverse

4. Clinical Particulars

4.1 Therapeutic Indications

Tagamet is a histamine H₂-receptor antagonist which rapidly inhibits both basal and stimulated gastric secretion of acid and reduces pepsin output.

Tagamet is indicated in the treatment of duodenal and benign gastric ulceration, including that associated with non-steroidal anti-inflammatory agents, recurrent and stomal ulceration, oesophageal reflux disease and other conditions where reduction of gastric acid by Tagamet has been shown to be beneficial: persistent dyspeptic symptoms with or without ulceration, particularly meal-related upper abdominal pain, including such symptoms associated with non-steroidal anti-inflammatory agents; the prophylaxis of gastrointestinal haemorrhage from stress ulceration in critically ill patients; before general anaesthesia in patients thought to be at risk of acid aspiration (Mendelson's) syndrome, particularly obstetric patients during labour; to reduce malabsorption and fluid loss in the short bowel syndrome; and in pancreatic insufficiency to reduce degradation of enzyme supplements. Tagamet is also recommended in the management of the Zollinger-Ellison syndrome.

4.2 Posology And Method Of Administration

The total daily dose should not normally exceed 2.4g. Dosage should be reduced in patients with impaired renal function (see Section 4.4).

Adults: For patients with duodenal or benign gastric ulceration a single dose of 800 mg at bedtime is recommended. Otherwise the usual dose is 400 mg twice a day with breakfast and at bedtime. Other effective regimens are 200 mg three times a day with meals and 400 mg at bedtime (1.0 g/day) and, if inadequate, 400 mg four times a day (1.6 g/day) also with meals and at bedtime.

Treatment should be given initially for at least four weeks (six weeks in benign gastric ulcer, eight weeks in ulcer associated with continued non-steroidal anti-inflammatory agents). even if symptomatic relief has been achieved sooner. Most ulcers will have healed by that stage, but those which have not will usually do so after a further course of treatment.

Treatment may be continued for longer periods in those patients who may benefit from reduction of gastric secretion and the dosage may be reduced in those who have responded to treatment, for example to 400mg at bedtime or 400mg in the morning and at bedtime.

In patients with benign peptic ulcer disease who have responded to the initial course, relapse may be prevented by continued treatment, usually with 400mg at bedtime; 400mg in the morning and at bedtime has also been used.

In oesophageal reflux disease, 400mg four times a day, with meals and at bedtime, for four to eight weeks is recommended to heal oesophagitis and relieve associated symptoms.

In patients with very high gastric acid secretion (e.g. Zollinger-Ellison syndrome) it may be necessary to increase the dose to 400mg four times a day, or in occasional cases further.

Since cimetidine may not give immediate symptomatic relief antacids can be made available to all patients until symptoms disappear.

In the prophylaxis of haemorrhage from stress ulceration in seriously ill patients, doses of 200-400mg can be given every four to six hours.

In patients thought to be at risk of acid aspiration syndrome an oral dose of 400mg can be given 90-120 minutes before induction of general anaesthesia or, in obstetric practice, at the start of labour. While such a risk persists, a dose of up to 400mg may be repeated at four hourly intervals as required up to the usual daily maximum of 2.4g. The usual precautions to avoid acid aspiration should be taken.

In the short bowel syndrome, e.g. following substantial resection for Crohn's disease, the usual dosage range (see above) can be used according to individual response.

To reduce degradation of pancreatic enzyme supplements, 800-1600mg a day may be given according to response in four divided doses, one to one and a half hours before meals.

Elderly: The normal adult dosage may be used unless renal function is markedly impaired. (see Section 4.4)

Children: Experience in children is less than that in adults. In children more than one year old, Tagamet 25-30mg/kg body weight per day in divided doses may be administered.

The use of Tagamet in infants under one year old is not yet fully evaluated; 20mg/kg body weight per day in divided doses has been used.

Administration: Oral; the tablets should be swallowed with a drink of water.

4.3 Contraindications

Hypersensitivity to cimetidine.

4.4 Special Warnings And Precautions For Use

Dosage should be reduced in patients with impaired renal function according to creatinine clearance. The following dosages are suggested: creatinine clearance of 0-15ml per minute, 200mg twice a day; 15 to 30ml per minute, 200mg three times a day; 30 to 50ml per minute, 200mg four times a day; over 50ml per minute, normal dosage. Cimetidine is removed by haemodialysis, but not to any significant extent by peritoneal dialysis.

Clinical trials of over six years' continuous treatment and more than 15 years' widespread use have not revealed unexpected adverse reactions related to long-term therapy

The safety of prolonged use is not fully established and care should be taken to observe periodically patients given prolonged treatment.

Care should be taken that patients with a history of peptic ulcer, particularly the elderly, being treated with cimetidine and a non-steroidal anti-inflammatory agent are observed regularly.

Before initiating therapy with this preparation for any gastric ulceration, malignancy should be excluded by endoscopy and biopsy, if possible, because Tagamet tablets can relieve the symptoms and help the superficial healing of the gastric cancer. The consequences of potential delay in diagnosis should be borne in mind especially in middle aged patients or over, with new or recently changed dyspeptic symptoms.

Due to possible interaction with coumarins, close monitoring of prothrombin time is recommended when cimetidine is concurrently used.

Co-administration of therapeutic agents with a narrow therapeutic index, such as phenytoin or theophylline, may require dosage adjustment when starting or stopping concomitantly administered cimetidine (see Section 4.5).

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Cimetidine can prolong the elimination of drugs metabolised by oxidation in the liver.

Although pharmacological interactions between cimetidine and a number of drugs have been demonstrated e.g. diazepam and propranolol, only those with oral anticoagulants, phenytoin, theophylline and intravenous lidocaine appear, to date, to be of clinical significance. Close monitoring of patients on cimetidine receiving oral anticoagulants or phenytoin is recommended and a reduction in the dosage of these drugs may be necessary.

In patients on drug treatment or with illnesses that could cause falls in blood cell count, the possibility that H₂-receptor antagonism could potentiate this effect should be borne in mind.

Cimetidine has the potential to affect the absorption, metabolism or renal excretion of other drugs which is particularly important when drugs with a narrow therapeutic index are administered concurrently. The altered pharmacokinetics may necessitate dosage adjustment of the affected drug or discontinuation of treatment (see Section 4.4).

Interactions may occur by several mechanisms including:

1) Inhibition of certain cytochrome P450 enzymes (including CYP1A2, CYP2C9, CYP2D6 and CYP3A3/A4, and CYP2C18); Inhibition of these enzymes may result in increased plasma levels of certain drugs including warfarin-type coumarin anticoagulants (e.g. warfarin), tricyclic antidepressants (e.g. amitriptyline), class I antiarrhythmics (e.g. lidocaine), calcium channel blockers (e.g. nifedipine, diltiazem), oral sulfonylureas (e.g. glipizide), phenytoin, theophylline and metoprolol.

2) Competition for renal tubular secretion; This may result in increased plasma levels of certain drugs including procainamide, metformin, ciclosporin and tacrolimus.

3) Alteration of gastric pH; The bioavailability of certain drugs may be affected. This can result in either an increase in absorption (e.g. atazanavir) or a decrease in absorption (e.g. some azole antifungals such as ketoconazole, itraconazole or posaconazole).

4) Unknown mechanisms; Cimetidine may potentiate the myelosuppressive effects (e.g. neutropenia, agranulocytosis) of chemotherapeutic agents such as carmustine, fluorouracil, epirubicin, or therapies such as radiation. Isolated cases of clinically relevant interactions have been documented with narcotic analgesics (e.g. morphine).

4.6 Pregnancy And Lactation

Although tests in animals and clinical evidence have not revealed hazards from the administration of Tagamet during pregnancy or lactation, both animal and human studies have shown that it does cross the placental barrier and is excreted in milk. As with most drugs, the use of this preparation during pregnancy and lactation should be avoided unless considered essential.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

Adverse experiences with cimetidine are listed below by system organ class and frequency. Frequencies are defined as: very common (>1/10), common (>1/100, <1/10), uncommon (>1/1000, <1/100), rare (>1/10000, <1/1000), very rare (<1/10000).

Blood and lymphatic system disorders

Uncommon: Leukopenia

Rare: Thrombocytopenia, aplastic anaemia

Very rare: Pancytopenia, agranulocytosis

Immune system disorders

Very rare: Anaphylaxis. Anaphylaxis is usually cleared on withdrawal of the drug.

Psychiatric disorders

Uncommon: Depression, confusional states, hallucinations. Confusional states, reversible within a few days of withdrawing cimetidine, have been reported, usually in elderly or ill patients.

Nervous system disorders

Common: Headache, dizziness

Cardiac disorders

Uncommon: Tachycardia

Rare: Sinus bradycardia

Very rare: Heart block

Gastrointestinal disorders

Common: Diarrhoea

Very rare: Pancreatitis. Pancreatitis cleared on withdrawal of the drug.

Hepatobiliary disorders

Uncommon: Hepatitis

Rare: Increased serum transaminase levels. Hepatitis and increased serum transaminase levels cleared on withdrawal of the drug.

Skin and subcutaneous tissue disorders

Common: Skin rashes

Very rare: Reversible alopecia and hypersensitivity vasculitis. Hypersensitivity vasculitis usually cleared on withdrawal of the drug.

Musculoskeletal and connective tissue disorders

Common: Myalgia

Very rare: Arthralgia

Renal and urinary disorders

Uncommon: Increases in plasma creatinine

Rare: Interstitial nephritis. Interstitial nephritis cleared on withdrawal of the drug. Small increases in plasma creatinine have been reported, unassociated with changes in glomerular filtration rate. The increases do not progress with continued therapy and disappear at the end of therapy.

Reproductive system and breast disorders

Uncommon: Gynaecomastia and reversible impotence. Gynaecomastia is usually reversible upon discontinuation of cimetidine therapy. Reversible impotence has been reported particularly in patients receiving high doses (e.g. in Zollinger-Ellison Syndrome). However, at regular dosage, the incidence is similar to that in the general population.

Very rare: Galactorrhoea

General disorders and administration site conditions

Common: Tiredness

Very rare: Fever. Fever cleared on withdrawal of the drug.

4.9 Overdose

Acute overdosage of up to 20g has been reported several times with no significant ill-effects. Induction of vomiting and/or gastric lavage may be employed together with symptomatic and supportive therapy.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Cimetidine, one of the H2 blockers is a reversible, competitive antagonist of the actions of histamine on H2 receptors. It is highly selective in its action and is virtually without effect on H1 receptors or, indeed on receptors for other autacoids or drugs. The most prominent of the effects of histamine that are mediated by H2 receptors is stimulation of gastric acid secretion and they interfere remarkably little with physiological functions other than gastric secretion.

Cimetidine inhibits gastric acid secretion elicited by histamine or other H2 agonists in a dose-dependent, competitive manner; the degree of inhibition parallels the plasma concentration of the drug over a wide range. In addition, the H2 blockers inhibit gastric secretion elicited by muscarinic agonists or by gastrin, although this effect is not always complete.

This breadth of inhibitory effect is not due to non-specific actions at the receptors for these other secretagogues. Rather, this effect, which is non-competitive and indirect, appears to indicate either that these two classes of secretagogues utilise histamine as the final common mediator or, more probably, that ongoing histaminergic stimulation of the parietal cell is important for amplification of the stimuli provided by ACh or gastrin when they act on their own discrete receptors. Receptors for all three secretagogues are present on the parietal cell. The ability of H2 blockers to suppress responses to all three physiological secretagogues makes them potent inhibitors of all phases of gastric acid secretion. Thus these drugs will inhibit basal (fasting) secretion and nocturnal secretion and also that stimulated by food, sham feeding, fundic distension, insulin, or caffeine. The H2 blockers reduce both the volume of gastric juice secreted and its hydrogen ion concentration. Output of pepsin, which is secreted by the chief cells of the gastric glands (mainly under cholinergic control), generally falls in parallel with the reduction in volume of the gastric juice. Secretion of intrinsic factor is also reduced, but it is normally secreted in great excess, and absorption of vitamin B12 is usually adequate even during long-term therapy with H2 blockers.

Concentrations of gastrin in plasma are not significantly altered under fasting conditions; however, the normal prandial elevation of gastrin concentration may be augmented, apparently as a consequence of a reduction in the negative feedback that is normally provided by acid.

5.2 Pharmacokinetic Properties

Cimetidine is rapidly and virtually completely absorbed. Absorption is little impaired by food or by antacids. Peak concentrations in plasma are attained in about 1 to 2 hours. Hepatic first-pass metabolism results in bioavailabilities of about 60% for cimetidine. The elimination half-life is about 2 to 3 hours. Cimetidine is eliminated primarily by the kidneys, and 60% or more may appear in the urine unchanged; much of the rest is oxidation products. Small amounts are recovered in the stool.

5.3 Preclinical Safety Data

Not available.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Microcrystalline cellulose

Povidone 30

Sodium starch glycollate

Sodium lauryl sulphate

Colloidal anhydrous silica

Magnesium stearate

Hypromellose (E464)

Titanium dioxide (E171)

Macrogol 400

Indigo carmine aluminium lake (E132)

Iron oxide yellow (E172)

Quinoline yellow aluminium lake (E104).

6.2 Incompatibilities

Not applicable

6.3 Shelf Life

3 years

6.4 Special Precautions For Storage

1. Blister: Do not store above 25°C. Store in the original package. Keep blister in the outer carton.

2. Tablet container (polypropylene tube): Do not store above 25°C. Keep the container tightly closed. Store in the original container.

6.5 Nature And Contents Of Container

1. Blister packs consisting of 250µm clear PVC and 20µm hard temper aluminium foil contained in a carton.

Pack sizes: 30 tablets.

2. Polypropylene tubes with low density polyethylene caps. High density polyethylene film may be used as packing material.

Pack sizes: 28, 60, 100, 150 and 250 tablets.

6.6 Special Precautions For Disposal And Other Handling

Not applicable.

Administrative Data

7. Marketing Authorisation Holder

Chemidex Pharma Limited

Chemidex House

Egham Business Village

Crabtree Road

Egham

Surrey TW20 8RB

United Kingdom

8. Marketing Authorisation Number(S)

PL 17736/0022

9. Date Of First Authorisation/Renewal Of The Authorisation

23 December 2002

10. Date Of Revision Of The Text

February 2009

Tanvimil C

Tanvimil C may be available in the countries listed below.

Ingredient matches for Tanvimil C

Ascorbic Acid

Ascorbic Acid is reported as an ingredient of Tanvimil C in the following countries:

Argentina

International Drug Name Search

Ketalgin

Ketalgin may be available in the countries listed below.

Ingredient matches for Ketalgin

Ketorolac

Ketorolac tromethamine (a derivative of Ketorolac) is reported as an ingredient of Ketalgin in the following countries:

Russian Federation

Methadone

Methadone hydrochloride (a derivative of Methadone) is reported as an ingredient of Ketalgin in the following countries:

Switzerland

International Drug Name Search

Selepen

Generic Name: selenium supplement (Oral route)

Commonly used brand name(s)

In the U.S.

Se Aspartate

Selepen

Available Dosage Forms:

Tablet

Capsule

Tablet, Extended Release

Uses For Selepen

Selenium supplements are used to prevent or treat selenium deficiency.

The body needs selenium for normal growth and health. Selenium is needed for certain enzymes that help with normal body functions.

Although selenium is being used to prevent certain types of cancer, there is not enough information to show that this is effective.

Importance of Diet

For good health, it is important that you eat a balanced and varied diet. Follow carefully any diet program your health care professional may recommend. For your specific dietary vitamin and/or mineral needs, ask your health care professional for a list of appropriate foods. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement.

Selenium is found in seafood, liver, lean red meat, and grains grown in soil that is rich in selenium.

The daily amount of selenium needed is defined in several different ways.

For U.S.—

Recommended Dietary Allowances (RDAs) are the amount of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. RDAs for a given nutrient may vary depending on a person's age, sex, and physical condition (e.g., pregnancy).

Daily Values (DVs) are used on food and dietary supplement labels to indicate the percent of the recommended daily amount of each nutrient that a serving provides. DV replaces the previous designation of United States Recommended Daily Allowances (USRDAs)

For Canada—

Recommended Nutrient Intakes (RNIs) are used to determine the amounts of vitamins, minerals, and protein needed to provide adequate nutrition and lessen the risk of chronic disease.

Normal daily recommended intakes for selenium are generally defined as follows:

Birth to 3 years of age: 10 to 20 micrograms (mcg) per day.

4 to 6 years of age: 20 mcg per day.

7 to 10 years of age: 30 mcg per day.

Adolescent and adult males—40 to 70 mcg per day.

Adolescent and adult females—45 to 55 mcg per day.

Pregnant females—65 mcg per day.

Breast-feeding females—75 mcg per day.

Before Using Selepen

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Problems in children have not been reported with intake of normal daily recommended amounts.

Geriatric

Problems in older adults have not been reported with intake of normal daily recommended amounts.

Pregnancy

It is especially important that you are receiving enough vitamins and minerals when you become pregnant and that you continue to receive the right amount of vitamins and minerals throughout your pregnancy. The healthy growth and development of the fetus depend on a steady supply of nutrients from the mother. However, taking large amounts of a dietary supplement in pregnancy may be harmful to the mother and/or fetus and should be avoided.

Studies in animals have shown that selenium causes birth defects when given in large doses.

Breast Feeding

It is important that you receive the right amounts of vitamins and minerals so that your baby will also get the vitamins and minerals needed to grow properly. However, taking large amounts of a dietary supplement while breast-feeding may be harmful to the mother and/or baby and should be avoided.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Eltrombopag

Interactions with Food/Tobacco/Alcohol

Proper Use of selenium supplement

This section provides information on the proper use of a number of products that contain selenium supplement. It may not be specific to Selepen. Please read with care.

Dosing

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

For selenium:
- For oral dosage form (tablets):
  - To prevent deficiency, the amount is based on normal daily recommended intakes:
    - Adult and teenage males—40 to 70 micrograms (mcg) per day.
    - Adult and teenage females—45 to 55 mcg per day.
    - Pregnant females—65 mcg per day.
    - Breast-feeding females—75 mcg per day.
    - Children 7 to 10 years of age—30 mcg per day.
    - Children 4 to 6 years of age—20 mcg per day.
    - Children birth to 3 years of age—10 to 20 mcg per day.
      - To treat deficiency:
        Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not refrigerate. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Selepen Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Diarrhea

fingernail weakening

garlic odor of breath and sweat

hair loss

irritability

itching of skin

nausea and vomiting

unusual tiredness and weakness

More Selepen resources

Selepen Drug Interactions
Selepen Support Group
0 Reviews · Be the first to review/rate this drug

Selenium Foam MedFacts Consumer Leaflet (Wolters Kluwer)

Selenium Prescribing Information (FDA)

Selenium Sulfide Monograph (AHFS DI)

Y Tex PYthon

Y Tex PYthon may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Y Tex PYthon

Cypermethrin

Cypermethrin is reported as an ingredient of Y Tex PYthon in the following countries:

Australia

Piperonyl Butoxide

Piperonyl Butoxide is reported as an ingredient of Y Tex PYthon in the following countries:

Australia

International Drug Name Search

Wednesday, September 28, 2016

calcium carbonate

Generic Name: calcium carbonate (KAL see um KAR boe nate)

Brand names: Alka-Mints, Cal-Gest, Calcarb, Calci Mix, Calci-Chew, Calci-Mix, Calcium Concentrate, Calcium Liquid Softgel, Calcium Oyster Shell, Caltrate, Chooz, Extra Strength Mylanta Calci Tabs, Icar Prenatal Chewable Calcium, Maalox Antacid Barrier, Maalox Childrens', Maalox Quick Dissolve, Maalox Quick Dissolve Maximum Strength, Maalox Regular Strength, Mylanta Child, Nephro Calci, Os-Cal 500, Oysco 500, Oyst Cal 500, Oyster Cal, Oyster Calcium, Oyster Shell, Pepto Children's, Rolaids Sodium Free, Rolaids Soft Chew, Titralac, Tums, Tums 500, Tums E-X, Tums Kids, Tums QuikPak, Tums Ultra, ...show all 58 brand names.

What is calcium carbonate?

Calcium is a mineral that is found naturally in foods. Calcium is necessary for many normal functions of the body, especially bone formation and maintenance. Calcium can also bind to other minerals (such as phosphate) and aid in their removal from the body.

Calcium carbonate is used to prevent and to treat calcium deficiencies.

Calcium carbonate may also be used for purposes not listed in this medication guide.

What is the most important information I should know about calcium carbonate?

Do not take calcium carbonate or antacids that contain calcium without first asking your doctor if you also take other medicines. Calcium can make it harder for your body to absorb certain medicines. Calcium carbonate works best if you take it with food.

What should I discuss with my healthcare provider before taking calcium carbonate?

To make sure you can safely take calcium carbonate, tell your doctor if you have any of these other conditions:

a history of kidney stones; or

a parathyroid gland disorder.

Talk to your doctor before taking calcium carbonate if you are pregnant. Talk to your doctor before taking calcium carbonate if you are breast-feeding a baby.

How should I take calcium carbonate?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Calcium carbonate works best if you take it with food. Swallow the calcium carbonate tablet or capsule with a full glass of water.

The chewable tablet should be chewed before you swallow it.

Use the calcium carbonate powder as directed. Allow the powder to dissolve completely, then consume the mixture.

Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, decreased appetite, constipation, confusion, delirium, stupor, and coma.

What should I avoid while taking calcium carbonate?

Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity.

Calcium carbonate side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

nausea or vomiting;

decreased appetite;

constipation;

dry mouth or increased thirst; or

urinating more than usual.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Calcium carbonate Dosing Information

Usual Adult Dose for Osteoporosis:

2500 to 7500 mg/day orally in 2 to 4 divided doses.

Usual Adult Dose for Hypocalcemia:

900 to 2500 mg/day orally in 2 to 4 divided doses. This dose may be adjusted as needed to achieve a normal serum calcium level.

Usual Adult Dose for Dyspepsia:

300 to 8000 mg/day orally in 2 to 4 divided doses. This dose may be increased as needed and tolerated to decrease symptoms of stomach upset.
Maximum Dose: 5,500 to 7980 mg (depending on product used). Not to exceed maximum daily dosage for a period of greater than 2 weeks unless directed by a physician.

Usual Adult Dose for Duodenal Ulcer:

1250 to 3750 mg/day in 2 to 4 divided doses. This dose may be increased as needed and tolerated to decrease the abdominal discomfort. The major limiting factor to the chronic use of calcium carbonate is gastric hypersecretion and acid rebound.

Usual Adult Dose for Gastric Ulcer:

Usual Adult Dose for Erosive Esophagitis:

1250 to 3750 mg/day orally in 2 to 4 divided doses. The potential for acid rebound could be detrimental. However, antacids have been frequently used in the management of erosive esophagitis and may be beneficial in decreasing the acidity of gastric contents.
Maximum Dose: 5,500 to 7980 mg (depending on product used). Not to exceed maximum daily dosage for a period of greater than 2 weeks unless directed by a physician.

Usual Adult Dose for Gastroesophageal Reflux Disease:

Usual Pediatric Dose for Hypocalcemia:

Neonatal:
Hypocalcemia (dose depends on clinical condition and serum calcium level): Dose expressed in mg of elemental calcium: 50 to 150 mg/kg/day in 4 to 6 divided doses; not to exceed 1 g/day

Usual Dosage:
Antacid:
Children 2 to 5 years: Childrens Pepto, Mylanta (R) Childrens: 1 tablet (400 mg calcium carbonate) as symptoms occur; not to exceed 3 tablets/day
Children 6 to 11 years: Childrens Pepto, Mylanta (R) Childrens: 2 tablets (800 mg calcium carbonate) as symptoms occur; not to exceed 6 tablets/day
Children 11 years and older:
Tums (R), Tums (R) E-X: 2 to 4 tablets chewed as symptoms occur; not to exceed 15 tablets [Tums (R)] or 10 tablets [Tums (R) E-X] per day
Tums (R) Ultra: 2 to 3 tablets chewed as symptoms occur; not to exceed 7 tablets per day
Hypocalcemia (dose depends on clinical condition and serum calcium level): Dose expressed in mg of elemental calcium:
Children: 45 to 65 mg/kg/day in 4 divided doses

Treatment of hyperphosphatemia in end-stage renal failure: Children and Adults: Dose expressed in mg of calcium carbonate: 1 g with each meal; increase as needed; range: 4 to 7 g/day

Hydrofluoric acid (HF) burns (HF concentration less than 20%): Topical: Various topical calcium preparations have been used anecdotally for treatment of dermal exposure to HF solutions; calcium carbonate at concentrations ranging from 2.5% to 33% has been used; a topical calcium carbonate preparation must be compounded.

What other drugs can affect calcium carbonate?

Calcium carbonate can make it harder for your body to absorb other medications you take by mouth. Tell your doctor if you are taking:

digoxin (Lanoxin, Lanoxicaps);

antacids or other calcium supplements;

calcitriol (Rocaltrol) or vitamin D supplements; or

doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

This list is not complete and other drugs may interact with calcium carbonate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More calcium carbonate resources

Calcium carbonate Side Effects (in more detail)
Calcium carbonate Use in Pregnancy & Breastfeeding
Drug Images
Calcium carbonate Drug Interactions
Calcium carbonate Support Group
4 Reviews for Calcium carbonate - Add your own review/rating

Calcium Carbonate MedFacts Consumer Leaflet (Wolters Kluwer)

Titralac Consumer Overview

Titralac MedFacts Consumer Leaflet (Wolters Kluwer)

Tums Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

Compare calcium carbonate with other medications

Duodenal Ulcer
Erosive Esophagitis
GERD
Hypocalcemia
Indigestion
Osteopenia
Osteoporosis
Stomach Ulcer

Where can I get more information?

Your doctor or pharmacist can provide more information about calcium carbonate.

See also: calcium carbonate side effects (in more detail)

Torisel

Generic Name: temsirolimus (Intravenous route)

tem-sir-OH-li-mus

Commonly used brand name(s)

In the U.S.

Torisel

Available Dosage Forms:

Solution

Therapeutic Class: Antineoplastic Agent

Uses For Torisel

Temsirolimus injection is an anticancer medicine that is used to treat advanced kidney cancer.

This medicine is available only with your doctor's prescription.

Before Using Torisel

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of temsirolimus injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies on the relationship of age to the effects of temsirolimus injection have not been performed in the geriatric population. However, elderly patients are more likely to have diarrhea, edema (swelling), and pneumonia, which may require caution in patients receiving temsirolimus injection.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Adenovirus Vaccine Type 4, Live

Adenovirus Vaccine Type 7, Live

Atazanavir

Bacillus of Calmette and Guerin Vaccine, Live

Carbamazepine

Clarithromycin

Dexamethasone

Indinavir

Influenza Virus Vaccine, Live

Itraconazole

Ketoconazole

Measles Virus Vaccine, Live

Mumps Virus Vaccine, Live

Nefazodone

Nelfinavir

Phenobarbital

Phenytoin

Poliovirus Vaccine, Live

Rifabutin

Rifampin

Ritonavir

Rotavirus Vaccine, Live

Rubella Virus Vaccine, Live

Saquinavir

Smallpox Vaccine

St John's Wort

Telithromycin

Typhoid Vaccine

Varicella Virus Vaccine

Voriconazole

Yellow Fever Vaccine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Grapefruit Juice

Proper Use of Torisel

Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for 30 to 60 minutes.

You will receive a medicine to prevent allergic reactions (e.g., diphenhydramine, Benadryl®) before you receive this medicine.

Precautions While Using Torisel

It is very important that your doctor check your progress at regular visits to see if the medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Men and women should use an effective form of birth control during treatment with temsirolimus and for at least 3 months after stopping treatment. If you think you have become pregnant while using this medicine, tell your doctor right away.

Temsirolimus may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash; itching; swelling of the face, tongue, and throat; trouble with breathing; or chest pain after you get the injection.

This medicine may cause flushing, headaches, and lightheadedness or faintness, while you are receiving the injection or within 24 hours after you receive it. Check with your doctor or nurse right away if you have any of these symptoms.

This medicine may increase the amount of sugar in your blood. Check with your doctor right away if you have increased thirst or urination. Your doctor may give you insulin or other medicines that can lower the amount of sugar in your blood.

While you are being treated with temsirolimus, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Temsirolimus may lower your body's resistance and there is a chance you might get the infection the vaccine is meant to prevent. In addition, other persons living in your household should not get live vaccines (e.g., nasal flu virus vaccine, measles, mumps, rubella, oral polio vaccine, BCG, yellow fever, varicella, or TY21a typhoid vaccine). Try to avoid being around persons who have received live vaccines. Do not get close to them, and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.

Treatment with temsirolimus may also increase the chance of getting other infections. If you can, avoid people with colds or other infections. If you think you are getting a cold or other infection, check with your doctor.

This medicine may cause a serious lung problem. Check with your doctor immediately if you are having tightness in the chest, shortness of breath, difficulty with breathing, or wheezing.

Temsirolimus may increase your cholesterol and fats in the blood. If this condition occurs, your doctor may give you some medicines that can lower the amount of cholesterol and fats in the blood.

Check with your doctor right away if you start having severe abdominal or stomach burning, cramps, or pains; bloody or black, tarry stools; diarrhea; fever; nausea; or vomiting of material that looks like coffee grounds. These could be symptoms of a serious bowel problem.

This medicine may increase your chance of having acute kidney disease that is not related to the worsening of your kidney cancer. Talk to your doctor about this risk.

This medicine may affect the way your body heals from cuts and wounds. Make sure any doctor who treats you knows that you are using this medicine. You may need to stop using this medicine several weeks before and after having surgery.

Grapefruit and grapefruit juice may increase the effects of temsirolimus by increasing the amount of medicine in your blood. You should not eat grapefruit or drink grapefruit juice while receiving this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (e.g., St. John's wort) or vitamin supplements.

Torisel Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Bladder pain

bloody nose

bloody or cloudy urine

body aches or pain

chest pain

congestion

cough or hoarseness

cracked lips

diarrhea

difficult or labored breathing

difficult, burning, or painful urination

difficulty with swallowing

dryness or soreness of the throat

fever or chills

frequent urge to urinate

headache

lack or loss of strength

lower back or side pain

shortness of breath

sneezing

sores, ulcers, or white spots on the lips, tongue, or inside the mouth

stomach pain

stuffy or runny nose

swelling of the hands, ankles, feet, or lower legs

swelling or puffiness of the face

tender, swollen glands in the neck

tightness in the chest

voice changes

vomiting

wheezing

Incidence not known

Blistering, peeling, or loosening of the skin

convulsions

dark-colored urine

itching

joint or muscle pain

muscle cramps or spasms

muscle stiffness

pain or redness at the injection site

pale skin at injection site

red skin lesions, often with a purple center

red, irritated eyes

unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Abdominal or stomach cramps

black, tarry stools

feeling that others are watching you or controlling your behavior

feeling that others can hear your thoughts

feeling, seeing, or hearing things that are not there

loss of bladder control

muscle spasm or jerking of all extremities

severe mood or mental changes

severe vomiting, sometimes with blood

sudden loss of consciousness

tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area

unusual behavior

More common

Back pain

blemishes on the skin

change in taste

difficulty having a bowel movement (stool)

difficulty with moving

discoloration of the fingernails or toenails

dry skin

loss of appetite

loss of taste

nausea

pain in the joints

pimples

rash

sleeplessness

swollen joints

trouble with sleeping

unable to sleep

weight loss

Less common

Discouragement

feeling sad or empty

irritability

loss of interest or pleasure

tiredness

trouble concentrating

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Torisel side effects (in more detail)

More Torisel resources

Torisel Side Effects (in more detail)
Torisel Use in Pregnancy & Breastfeeding
Torisel Drug Interactions
Torisel Support Group
0 Reviews for Torisel - Add your own review/rating

Torisel Prescribing Information (FDA)

Torisel Consumer Overview

Torisel Monograph (AHFS DI)

Torisel MedFacts Consumer Leaflet (Wolters Kluwer)

Temsirolimus Professional Patient Advice (Wolters Kluwer)

Compare Torisel with other medications

Renal Cell Carcinoma

Tuesday, September 27, 2016

Paroxetina Kern Pharma

Paroxetina Kern Pharma may be available in the countries listed below.

Ingredient matches for Paroxetina Kern Pharma

Paroxetine

Paroxetine hydrochloride (a derivative of Paroxetine) is reported as an ingredient of Paroxetina Kern Pharma in the following countries:

Spain

International Drug Name Search

technetium tc 99m pentetate Intravenous

tek-NEE-shee-um Tc 99m PEN-te-tate

Commonly used brand name(s)

In the U.S.

An-DTPA

MPI DTPA

Available Dosage Forms:

Therapeutic Class: Diagnostic Agent, Radiopharmaceutical Imaging

Uses For technetium tc 99m pentetate

Technetium Tc 99m pentetate injection is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents, which may be used to find and treat certain diseases or to study the function of the body's organs.

Technetium Tc 99m pentetate injection is used to help your doctor see an image of your kidneys and assess how well they are working. It is also used to help your doctor see an image of your brain.

technetium tc 99m pentetate is to be given only by or under the direct supervision of a doctor with specialized training in nuclear medicine.

Before Using technetium tc 99m pentetate

In deciding to use a diagnostic test, any risks of the test must be weighed against the good it will do. This is a decision you and your doctor will make. Also, other things may affect test results. For this test, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to technetium tc 99m pentetate or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of technetium Tc 99m pentetate injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of technetium Tc 99m pentetate injection in geriatric patients.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Proper Use of technetium tc 99m pentetate

A doctor or other trained health professional will give you technetium tc 99m pentetate. technetium tc 99m pentetate is given through a needle placed in one of your veins before you have a brain or kidney scan.

You will need to urinate right away and as often as possible for 4 to 6 hours after receiving technetium tc 99m pentetate. Drink plenty of fluids before and after receiving technetium tc 99m pentetate so you will pass more urine.

Precautions While Using technetium tc 99m pentetate

It is very important that your doctor check you closely while you are receiving technetium tc 99m pentetate. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it.

While using technetium tc 99m pentetate, you may be exposed to radiation. Talk with your doctor if you have concerns about this.

technetium tc 99m pentetate Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

Cough

difficulty with swallowing

dizziness

fast heartbeat

fever

hives

itching

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

shortness of breath

skin rash

tightness in the chest

unusual tiredness or weakness

wheezing

Incidence not known

Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Friday, September 30, 2016

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Thursday, September 29, 2016

1. Name Of The Medicinal Product

2. Qualitative And Quantitative Composition

3. Pharmaceutical Form

4. Clinical Particulars

4.1 Therapeutic Indications

4.2 Posology And Method Of Administration

4.3 Contraindications

4.4 Special Warnings And Precautions For Use

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

4.6 Pregnancy And Lactation

4.7 Effects On Ability To Drive And Use Machines

4.8 Undesirable Effects

4.9 Overdose

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

5.2 Pharmacokinetic Properties

5.3 Preclinical Safety Data

6. Pharmaceutical Particulars

6.1 List Of Excipients

6.2 Incompatibilities

6.3 Shelf Life

6.4 Special Precautions For Storage

6.5 Nature And Contents Of Container

6.6 Special Precautions For Disposal And Other Handling

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